Chemical and Pharmacological Profile of Psidium guajava: A Mini Review

Chemical and Pharmacological Profile of Psidium guajava: A Mini Review

Authors

  •   Kapil Dev   Academy of Scientific and Innovative Research, Ghaziabad - 201002
  •   Shraddha Srivastava   Phytochemistry Division, CSIR-Central Institute of Medicinal and Aromatic Plants, Lucknow-226015
  •   Rohit Bisht   Phytochemistry Division, CSIR-Central Institute of Medicinal and Aromatic Plants, Lucknow-226015

DOI:

https://doi.org/10.36808/if/2022/v148i4/168880

Keywords:

Psidium guajava, Guava, Myrtaceae, Phytochemistry, Pharmacology, Meroterpenoids.

Abstract

Psidium guajava, is an important medicinal plant in the tropical and subtropical regions of the world. It is mainly cultivated as a food crop throughout the world. The plant has been widely used as nutritious food and folk medicine in several disorders. Several secondary metabolites belonging to meroterpenoids, phenolics, flavonoids, flavonoid glycosides, carotenoids, terpenoids have been isolated from different parts of the plant. The extracts and metabolites mainly from leaves and fruits possess various pharmacological activities. The literature survey showed that P. guajava is mainly known for its antispasmodic, hypoglycemic, and antidiarrheal properties. The fruits are rich in flavonoids and phenolics, hence exhibiting potent antioxidant activity. The plant is also reported for several other pharmacological properties such as hepatoprotective, antimicrobial, antiplasmodial, cytotoxic, cardioprotective, antiosteoporotic, antinociceptive activities, etc. The review aims to compile the chemical profile and pharmacological properties of the plant.

References

Askar A., El-Nemr S.E. and Bassiouny S.S. (1986). Aroma constituents in white and pink guava fruits, Alimenta, 25(6): 162167.

Begum S., Hassan S.I., Ali S.N. and Siddiqui B.S. (2004). Chemical constituents from the leaves of Psidium guajava, Nat. Prod. Res., 18(2): 135-140.

Begum S., Hassan S.I. and Siddiqui B.S. (2002). Two new triterpenoids from the fresh leaves of Psidium guajava, Planta Med., 68(12): 1149-1152.

Begum S., Hassan S.I., Siddiqui B.S., Shaheen F., Ghayur M.N. and Gilani A.H. (2002). Triterpenoids from the leaves of Psidium guajava, Phytochemistry 61(4): 399-403.

Chah K.F., Eze C.A., Emuelosi C.E. and Esimone C.O. (2006). Antibacterial and wound healing properties of methanolic extracts of some Nigerian medicinal plants, J. Ethnopharmacol., 104: 164-167.

Chalannavar R.K., Venugopala K.N., Baijnath H. and Odhav B. (2014). The chemical composition of leaf essential oils of Psidium guajava L. (white and pink fruit forms) from South Africa, J. Essent. Oil-Bear. Plants, 17(6): 1293-1302.

Chang W.-C. and Shen S.-C. (2013). Effect of water extracts from edible myrtaceae plants on uptake of 2-(N-(7-nitrobenz-2oxa-1,3-diazol-4-yl)amino)-2-deoxyglucose in TNF-α-treated FL83B mouse hepatocytes, Phytother. Res., 27(2): 236-243.

Denny, C., Melo, P.S., Franchin, M., Massarioli A.P., Bergamaschi K.B., de Alencar S. M. and Rosalen P.L. (2013). Guava pomace: a new source of anti-inflammatory and analgesic bioactives, BMC Complement Altern. Med., 13: 235-235.

El-Haddad A.E., Sheta N.M. and Boshra S.A. (2018). Isolation, formulation, and efficacy enhancement of morin emulsified carriers against lung toxicity in rats, AAPS PharmSciTech., 19(5): 2346-2357.

Fu H.-Z., Luo Y.-M., Li C.-J., Yang J.-Z. and Zhang D.-M. (2010). Psidials A-C, three unusual meroterpenoids from the leaves of Psidium guajava L., Org. Lett., 12(4): 656-659.

Gao Y., Wang G.-Q., Wei K., Hai P., Wang F. and Liu J.-K. (2012). Isolation and biomimetic synthesis of (±)-guajadial B: a novel meroterpenoid from Psidium guajava., Org. Lett., 14(23): 5936-5939.

Goncalves J.L., Lopes R.C., Oliveira D.B., Costa S.S., Miranda M.M., Romanos M.T., Santos N.S. and Wigg M.D. (2005). In vitro anti-rotavirus activity of some medicinal plants used in Brazil against diarrhea., J. Ethnopharmacol., 99(3): 403-407.

Gutierrez R.M.P., Mitchell S. and Solis R.V. (2008). Psidium guajava: A review of its traditional uses, phytochemistry and pharmacology. J. Ethnopharmacol., 117(1): 1-27.

Han E.H., Hwang Y.P., Kim H.G., Park J.H., Choi J.H., Im J.H., Khanal T., Park B.H., Yang J.H., Choi J.M., Chun S.-S., Seo J.K., Chung Y.C. and Jeong H.G. (2011). Ethyl acetate extract of Psidium guajava inhibits IgE-mediated allergic responses by blocking FcεRI signaling., Food Chem. Toxicol., 49(1): 100-108.

Li C.-J., Ma J., Sun H., Zhang D. and Zhang D.-M. (2016). Guajavadimer A, a dimeric caryophyllene-derived meroterpenoid with a new carbon skeleton from the leaves of Psidium guajava., Org. Lett., 18(2): 168-171.

Liang Q., Qian H. and Yao W. (2005). Identification of flavonoids and their glycosides by high-performance liquid chromatography with electrospray ionization mass spectrometry and with diode array ultraviolet detection. Eur. J. Mass Spectrom., 11(1): 93-101.

Lu P., Qian C. and Huang X. (2011). Determination of hyperin in Psidium guajava leaf by HPLC. Zhongguo Xiandai Yingyong Yaoxue, 28(6): 553-555.

Mercadante A.Z., Steck A. and Pfander H. (1999). Carotenoids from guava (Psidium guajava L.): Isolation and structure elucidation., J. Agric. Food Chem., 47(1): 145-151.

Morton J.F. (1987). Fruits of Warm Climates. Center for New Crops and Plant Products, Department of Horticulture and Landscape Architecture, Purdue University, West Lafayette, Indiana, Creative Resource Systems, Inc.

Oh W.K., Lee C.H., Lee M.S., Bae E.Y., Sohn C.B., Oh H., Kim B.Y. and Ahn J.S. (2005). Antidiabetic effects of extracts from Psidium guajava., J. Ethnopharmacol., 96(3): 411-415.

Ojewole J.A.O. (2005). Hypoglycemic and hypotensive effects of Psidium guajava Linn. (Myrtaceae) leaf aqueous extract. Methods Find. Exp. Clin. Pharmacol., 27(10): 689-695.

Okuda T., Hatano T. and Yazaki K. (1984). Guavin B, an ellagitannin of novel type. Chem. Pharm. Bull. 32(9): 3787-3788.

Oliveira D.D.S., Lobato A.L., Ribeiro S.M.R., Santana A.M.C., Chaves J.B.P. and Pinheiro-Sant'Ana H.M. (2010). Carotenoids and vitamin C during handling and distribution of guava (Psidium guajava L.), mango (Mangifera indica L.), and papaya (Carica papaya L.) at commercial restaurants. J. Agric. Food Chem., 58(10): 6166-6172.

Porwal K., Pal S., Dev K., China S.P., Kumar Y., Singh C., Barbhuyan T., Sinha N., Sanyal S., Trivedi A.K., Maurya R. and Chattopadhyay N. (2017). Guava fruit extract and its triterpene constituents have osteoanabolic effect: Stimulation of osteoblast differentiation by activation of mitochondrial respiration via the Wnt/β-catenin signaling. J. Nutr. Biochem., 44: 22-34.

Prabu G.R., Gnanamani A. and Sadulla S. (2006). Guaijaverin - a plant flavonoid as potential antiplaque agent against Streptococcus mutans., J. Appl. Microbiol., 101(2): 487-495.

Qadan F., Thewaini A.J., Ali D.A., Afifi R., Elkhawad A. and Matalka K.Z., (2005). The antimicrobial activities of Psidium guajava and Juglans regia leaf extracts to acne-developing organisms., Am. J. Chin. Med., 33(2): 197-204.

Rai P.K., Mehta S. and Watal G. (2010). Hypolipidaemic and hepatoprotective effects of Psidium guajava raw fruit peel in experimental diabetes., Indian J. Med. Res., 131: 820-824.

Rajendran C., Begam M., Kumar D., Baruah I., Gogoi H.K., Srivastava R.B. and Veer V. (2014). Antiplasmodial activity of certain medicinal plants against chloroquine resistant Plasmodium berghei infected white albino BALB/c mice. J. Parasit. Dis., 38(2): 148-152.

Rohde W. and Fermin G., et. al. (2010). Guava and other myrtaceae. (Proceedings of the IInd International Symposium, held in Merida, Mexico, November 10-13, 2008, Aguascalientes, Mexico, November 17-18, 2008), International Society for Horticultural Science.

Salib J.Y. and Michael H.N. (2004). Cytotoxic phenylethanol glycosides from Psidium guaijava seeds. Phytochemistry, 65(14): 2091-2093.

Shao M., Wang Y., Huang X.-J., Fan C.-L., Zhang Q.-W., Zhang X.-Q. and Ye W.-C. (2012). Four new triterpenoids from the leaves of Psidium guajava. J. Asian Nat. Prod. Res., 14(4): 348354.

Shao M., Wang Y., Jian Y.-Q., Huang X.-J., Zhang D.-M., Tang Q.-F., Jiang R.-W., Sun X.-G., Lv Z.-P., Zhang X.-Q. and Ye W.C. (2012). Guadial A and psiguadials C and D, three unusual meroterpenoids from Psidium guajava, Org. Lett., 14(20): 52625265.

Shao M., Wang Y., Jian Y.-Q., Sun X.-G., Huang X.-J., Zhang X.-Q. and Ye W.-C. (2014). Chemical constituents of leaves of Psidium guajava., Zhongguo Zhongyao Zazhi, 39(6): 1024-1029.

Shao M., Wang Y., Liu Z., Zhang D.-M., Cao H.-H., Jiang R.-W., Fan C.-L., Zhang X.-Q., Chen H.-R., Yao X.-S. and Ye W.-C. (2010). Psiguadials A and B, two novel meroterpenoids with unusual skeletons from the leaves of Psidium guajava., Org. Lett. 12(21): 5040-5043.

Stevens K.L., Brekke J.E. and Stern D.J. (1970). Volatile constituents in guava., J. Agric. Food Chem., 18(4): 598-599.

Tona L., Kambu K., Mesia K., Cimanga K., Apers S., De Bruyne T., Pieters L., Totté J., and Vlietinck A.J. (1999). Biological screening of traditional preparations from some medicinal plants used as antidiarrhoeal in Kinshasa, Congo. Phytomedicine, 6 (1): 59-66.

Yamanaka F., Hatano T., Ito H., Taniguchi S., Takahashi E. and Okamoto K. (2008). Antibacterial effects of guava tannins and related polyphenols on Vibrio and Aeromonas species, Nat. Prod. Commun., 3(5): 711-720.

Yang X.-L., Hsieh K.-L. and Liu J.-K. (2007). Guajadial: An Unusual Meroterpenoid from Guava Leaves Psidium guajava, Org. Lett., 9(24): 5135-5138.

Zhu M., Phillipson J.D., Greengrass P.M., Bowery N.E. and Cai Y. (1997). Plant polyphenols: biologically active compounds or nonselective binders to protein, Phytochemistry, 44(3): 441-447.

Downloads

Download data is not yet available.

Author Biography

Kapil Dev, Academy of Scientific and Innovative Research, Ghaziabad - 201002

uttarakhand

Published

2022-06-08

How to Cite

Dev, K., Srivastava, S., & Bisht, R. (2022). Chemical and Pharmacological Profile of <i>Psidium guajava</i>: A Mini Review. Indian Forester, 148(4), 415–422. https://doi.org/10.36808/if/2022/v148i4/168880

Issue

Section

Articles
Loading...